Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | MELK | Q14680 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 6/20 | 0.42 |
| ▸ | MAP2 | P11137 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | TOP1 | P11387 | 2/20 | 0.41 |
| ▸ | TOP2A | P11388 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842420 | 0.88 | PRKD1 (0.43) | BRD4MELKACHEPRKD1FGFR1 | |
| SCHEMBL15104126 | 0.88 | PRKD1 (0.46) | BRD4MELKACHEPRKD1 | |
| SCHEMBL1790523 | 0.85 | FLT3 (0.53) | BRD4MELKACHEPRKD1KDR | |
| SCHEMBL3850586 | 0.82 | RET (0.46) | BRD4MELKPRKD1FGFR1KDR | |
| Urea SCHEMBL5526915 | 0.80 | PRKD1 (0.47) | BRD4MELKACHEPRKD1KDR | |
| SCHEMBL5526921 | 0.80 | PRKD1 (0.41) | BRD4MELKACHEPRKD1FGFR1 | |
| SCHEMBL1790750 | 0.79 | PRKD1 (0.54) | BRD4MELKACHEPRKD1KDR | |
| SCHEMBL1792934 | 0.78 | PRKD1 (0.49) | BRD4MELKACHEPRKD1KDR | |
| SCHEMBL1792223 | 0.78 | FLT3 (0.60) | MELKACHEPRKD1KDRAURKA | |
| SCHEMBL1793036 | 0.77 | FLT3 (0.51) | MELKACHEPRKD1KDRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797072-A4 | PYRAZOLE KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-1797072-A2 | PYRAZOLE KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006033943-A2 | PYRAZOLE KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC (US) | 2006-03-30 | — | — | WO | disclosed |