Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 7/20 | 0.45 |
| ▸ | TOP1 | P11387 | 2/20 | 0.45 |
| ▸ | TOP2A | P11388 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842420 | 0.85 | PRKD1 (0.43) | BRD4TOP1TOP2AALDH1A1SMN1; SMN2 | |
| SCHEMBL15104126 | 0.84 | PRKD1 (0.46) | BRD4PRKD1MELK | |
| SCHEMBL3850883 | 0.82 | BRD4 (0.46) | BRD4TOP1TOP2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1790845 | 0.82 | PRKD1 (0.54) | RETBRD4TOP1TOP2AALDH1A1 | |
| SCHEMBL1790719 | 0.73 | PRKD1 (0.52) | BRD4TOP1TOP2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1788454 | 0.72 | DGAT1 (0.55) | BRD4TOP1TOP2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1790220 | 0.72 | KDR (0.59) | BRD4TOP1TOP2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5523487 | 0.72 | ALDH1A1 (0.57) | RETTOP1TOP2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5531729 | 0.70 | MELK (0.57) | KDRAURKAFLT3FLT1PRKD1 | |
| SCHEMBL27802443 | 0.70 | PRKD1 (0.51) | SMN1; SMN2FLT3PRKD1MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797072-A4 | PYRAZOLE KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-1797072-A2 | PYRAZOLE KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006033943-A2 | PYRAZOLE KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC (US) | 2006-03-30 | — | — | WO | disclosed |