Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 11/20 | 1.00 |
| ▸ | CYP2C8 | P10632 | 6/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.66 |
| ▸ | CYP2C18 | P33260 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | THPO | P40225 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | OXTR | P30559 | 4/20 | 0.51 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845328 | 0.84 | CYP2C9 (0.75) | CYP2C9CYP2C8CYP2C19CYP2C18LMNA | |
| SCHEMBL3849178 | 0.82 | CYP2C9 (0.71) | CYP2C9CYP2C8CYP2C19CYP2C18LMNA | |
| SCHEMBL3849522 | 0.80 | CYP2C9 (0.81) | CYP2C9CYP2C8CYP2C19CYP2C18LMNA | |
| Sulfaphenazole SCHEMBL122040 | 0.80 | CYP2C9 (1.00) | CYP2C9CYP2C8CYP2C19CYP2C18LMNA | |
| SCHEMBL5450995 | 0.76 | CYP2C9 (0.78) | CYP2C9CYP2C8CYP2C19CYP2C18LMNA | |
| SCHEMBL15834271 | 0.73 | CYP2C9 (0.69) | CYP2C9CYP2C8CYP2C19CYP2C18LMNA | |
| SCHEMBL23747737 | 0.72 | NAMPT (0.61) | CYP2C9CYP2C8CYP2C19CYP2C18LMNA | |
| Sulfaphenazole SCHEMBL13723748 | 0.72 | CYP2C9 (0.77) | CYP2C9CYP2C8CYP2C19CYP2C18LMNA | |
| SCHEMBL11267272 | 0.72 | CYP2C9 (0.77) | CYP2C9CYP2C8CYP2C19CYP2C18LMNA | |
| Sulfaphenazole SCHEMBL28086445 | 0.71 | CYP2C9 (0.80) | CYP2C9CYP2C8CYP2C19CYP2C18LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2011489-A2 | Method to inhibit ischemia and reperfusion injury | Gottlieb, Roberta (US) | 2009-01-07 | — | — | EP | disclosed |
| EP-1523310-A2 | METHOD TO INHIBIT ISCHEMIA AND REPERFUSION INJURY | The Scripps Research Institute (US) | 2005-04-20 | — | — | EP | disclosed |
| WO-2004004702-A2 | METHOD TO INHIBIT ISCHEMIA AND REPERFUSION INJURY | THE SCRIPPS RESEARCH INSTITUTE (US) | 2004-01-15 | — | — | WO | disclosed |