Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 7/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3852739 | 0.89 | CHRM4 (0.43) | GPR6CHRM4SCDCYP3A4HPGD | |
| SCHEMBL3847665 | 0.89 | CHRM4 (0.41) | CHRM4CYP3A4HPGDPDE10A | |
| SCHEMBL3855583 | 0.88 | GPR119 (0.41) | GPR6CHRM4 | |
| SCHEMBL3855214 | 0.86 | CHRM4 (0.41) | GPR6CHRM4OXTR | |
| SCHEMBL3848728 | 0.85 | CHRM4 (0.39) | CHRM4CYP3A4HPGDPDE10A | |
| SCHEMBL4715518 | 0.84 | CHRM4 (0.42) | GPR6CHRM4 | |
| SCHEMBL3855874 | 0.83 | CHRM4 (0.39) | CHRM4SCDCYP3A4HPGDPDE10A | |
| SCHEMBL3847786 | 0.82 | CHRM4 (0.36) | CHRM4CYP3A4HPGDPDE10A | |
| SCHEMBL5851864 | 0.81 | CYP3A4 (0.38) | CYP3A4HPGD | |
| SCHEMBL3852758 | 0.81 | CHRM4 (0.42) | CHRM4CYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |