⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3851603 | 1.00 | — | — | |
| SCHEMBL5747556 | 0.90 | CTH (0.43) | — | |
| SCHEMBL5747564 | 0.90 | CTH (0.43) | — | |
| SCHEMBL10866549 | 0.69 | — | — | |
| SCHEMBL24075919 | 0.65 | — | — | |
| SCHEMBL14613455 | 0.65 | — | — | |
| SCHEMBL16479485 | 0.64 | KDM4E (0.44) | — | |
| SCHEMBL9039273 | 0.64 | — | — | |
| SCHEMBL18980923 | 0.64 | — | — | |
| SCHEMBL9039277 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110759903-B | Novel synthesis method of thiabendazole | 南开大学 | 2022-10-28 | — | — | CN | disclosed |
| CN-110759903-B | Novel synthesis method of thiabendazole | 南开大学 | 2022-10-28 | — | — | CN | disclosed |
| US-20220227789-A1 | NOVEL INDOLIZINE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2022-07-21 | — | — | US | disclosed |
| EP-3962913-A1 | NOVEL INDOLIZINE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AiCuris GmbH & Co. KG (DE) | 2022-03-09 | — | — | EP | disclosed |
| CN-113748113-A | Novel indolizine-2-carboxamides having activity against Hepatitis B Virus (HBV) | 艾库里斯有限及两合公司 | 2021-12-03 | — | — | CN | disclosed |
| WO-2020221824-A1 | NOVEL INDOLIZINE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2020-11-05 | — | — | WO | disclosed |
| CN-110759903-A | Novel synthesis method of thiabendazole | 南开大学 | 2020-02-07 | — | — | CN | disclosed |
| CN-103180317-B | Heteroarylpiperidine and piperazine derivatives as fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-03-23 | — | — | CN | disclosed |
| CN-103180317-A | Heteroarylpiperidine and piperazine derivatives as fungicides | BAYER IP GMBH | 2013-06-26 | — | — | CN | disclosed |
| US-7579349-B2 | 4-(pyrazol-3-ylamino) pyrimidine derivatives for use in the treatment of cancer | ASTRAZENECA AB (SE) | 2009-08-25 | — | — | US | disclosed |
| EP-1678169-B1 | 4-(PYRAZOL-3-YLAMINO)PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2009-07-22 | — | — | EP | disclosed |
| US-20070037888-A1 | anticarcinogenic agent 5-Chloro-2-{2-[3-(pyrid-2-yl)isoxazol-5-yl]pyrrolidin-1-yl}-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidine; chemical synthesis; use in modulating insulin-like growth factor 1 receptor activity | ASTRAZENECA AB (SE) | 2007-02-15 | — | — | US | disclosed |
| CN-1894243-A | 4- (pyrazol-3-ylamino) pyrimidine derivatives for the treatment of cancer | ASTRAZENECA AB (SE) | 2007-01-10 | — | — | CN | disclosed |
| EP-1678169-A1 | 4-(PYRAZOL-3-YLAMINO)PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040159-A1 | 4-(PYRAZOL-3-YLAMINO) PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2005-05-06 | — | — | WO | disclosed |