Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27992610 | 0.81 | — | — | |
| SCHEMBL3844048 | 0.77 | KDM4E (0.38) | — | |
| SCHEMBL28066814 | 0.74 | ALDH1A1 (0.34) | ALDH1A1 | |
| SCHEMBL659895 | 0.70 | NPSR1 (0.37) | ALDH1A1 | |
| SCHEMBL17892425 | 0.67 | NPSR1 (0.37) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL31719805 | 0.66 | CYP4F2 (0.41) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL23363609 | 0.66 | NPSR1 (0.36) | ALDH1A1 | |
| Piperidine SCHEMBL28869229 | 0.65 | ALDH1A1 (0.47) | ALDH1A1 | |
| SCHEMBL13766457 | 0.65 | MAPT (0.35) | ALDH1A1 | |
| SCHEMBL6913918 | 0.64 | CYP1A2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834221-B1 | CYCLIC AMIDES AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2016-05-25 | — | — | EP | claimed |
| EP-2834221-B1 | CYCLIC AMIDES AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2016-05-25 | — | — | EP | disclosed |
| EP-2834221-A1 | CYCLIC AMIDES AS METAP-2 INHIBITORS | Merck Patent GmbH (DE) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013149704-A1 | CYCLIC AMIDES AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2013-10-10 | — | — | WO | disclosed |
| EP-2054053-A1 | BIPHENYL SUBSTITUTED SPIROTETRONIC ACIDS AND THEIR USE FOR THE TREATMENT OF RETROVIRAL DISORDERS | AiCuris GmbH & Co. KG (DE) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008022725-A1 | BIPHENYL SUBSTITUTED SPIROTETRONIC ACIDS AND THEIR USE FOR THE TREATMENT OF RETROVIRAL DISORDERS | AICURIS GMBH & CO. KG (DE) | 2008-02-28 | — | — | WO | disclosed |