Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 6/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3784431 | 0.78 | KDR (0.46) | MAP3K14KDRFYNPDPK1CYP2A6 | |
| SCHEMBL3781182 | 0.75 | KDR (0.66) | KDRPIK3CAFLT3PDPK1CYP2A6 | |
| SCHEMBL19585798 | 0.74 | MAP3K14 (0.56) | MAP3K14PIK3CAMTORFLT3FYN | |
| SCHEMBL4254179 | 0.74 | MAP3K14 (0.56) | MAP3K14KDRPIK3CAMTORFLT3 | |
| SCHEMBL15756965 | 0.72 | MAP3K14 (0.54) | MAP3K14KDRPIK3CAMTORFLT3 | |
| SCHEMBL3849727 | 0.71 | PIK3CA (0.53) | MAP3K14PIK3CAMTORFLT3FYN | |
| SCHEMBL3848111 | 0.71 | PIK3CA (0.44) | MAP3K14PIK3CAMTORFLT3GAA | |
| SCHEMBL3850491 | 0.71 | PIK3CA (0.44) | MAP3K14PIK3CAMTORFLT3FYN | |
| SCHEMBL3846827 | 0.71 | MAP3K14 (0.59) | MAP3K14PIK3CAMTORFLT3FYN | |
| SCHEMBL3846282 | 0.71 | MAP3K14 (0.43) | MAP3K14PIK3CAMTORFLT3FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |