Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.60 |
| ▸ | JAK3 | P52333 | 5/20 | 0.58 |
| ▸ | JAK1 | P23458 | 4/20 | 0.58 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.50 |
| ▸ | JAK2 | O60674 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 3/20 | 0.50 |
| ▸ | LYN | P07948 | 3/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 5/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.47 |
| ▸ | PAK4 | O96013 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | PRKCG | P05129 | 2/20 | 0.47 |
| ▸ | INSR | P06213 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2104246 | 0.91 | ADORA3 (0.62) | SYKJAK3JAK1TYRO3ADORA3 | |
| SCHEMBL2105664 | 0.89 | SYK (0.73) | SYKJAK3JAK1TYRO3ADORA3 | |
| SCHEMBL2104145 | 0.89 | SYK (0.62) | SYKJAK3JAK1TYRO3ADORA3 | |
| SCHEMBL2103190 | 0.85 | SYK (0.72) | SYKJAK3JAK1TYRO3ADORA3 | |
| SCHEMBL2102238 | 0.83 | SYK (0.67) | SYKJAK3JAK1TYRO3ADORA3 | |
| SCHEMBL2103470 | 0.83 | SYK (0.69) | SYKJAK3JAK1TYRO3ADORA3 | |
| SCHEMBL2103810 | 0.82 | ADORA3 (0.65) | SYKJAK3JAK1TYRO3ADORA3 | |
| SCHEMBL2102411 | 0.82 | SYK (0.67) | SYKJAK3JAK1TYRO3ADORA3 | |
| SCHEMBL2104040 | 0.82 | SYK (0.60) | SYKJAK3JAK1TYRO3ADORA3 | |
| SCHEMBL658794 | 0.81 | SYK (0.71) | SYKJAK3JAK1EGFRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2130541-A2 | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds | Rigel Pharmaceuticals, Inc. (US) | 2009-12-09 | — | — | EP | claimed |