Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.88 |
| ▸ | RAB9A | P51151 | 2/20 | 0.88 |
| ▸ | HTR7 | P34969 | 1/20 | 0.69 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14089801 | 0.91 | NPC1 (0.72) | NPC1RAB9AHTR7PTPN1MEN1 | |
| SCHEMBL9680520 | 0.89 | NPC1 (0.91) | NPC1RAB9AHTR7PTPN1MEN1 | |
| SCHEMBL3424496 | 0.87 | NPC1 (0.87) | NPC1RAB9AHTR7PTPN1MEN1 | |
| SCHEMBL9680984 | 0.87 | NPC1 (0.87) | NPC1RAB9AHTR7PTPN1MEN1 | |
| SCHEMBL1040636 | 0.87 | NPC1 (0.87) | NPC1RAB9AHTR7PTPN1MEN1 | |
| SCHEMBL296337 | 0.86 | NPC1 (0.84) | NPC1RAB9AHTR7PTPN1MEN1 | |
| SCHEMBL28197598 | 0.86 | NPC1 (0.84) | NPC1RAB9AHTR7MEN1KMT2A | |
| SCHEMBL14605918 | 0.86 | NPC1 (0.77) | NPC1RAB9AHTR7PTPN1MEN1 | |
| SCHEMBL26584242 | 0.84 | NPC1 (0.82) | NPC1RAB9AHTR7PTPN1MEN1 | |
| SCHEMBL27983192 | 0.84 | NPC1 (0.81) | NPC1RAB9AHTR7PTPN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885703-A4 | PROCESSES FOR PRODUCTION OF PHENOLIC 4-BIPHENYLYLAZETIDIN-2-ONES | MICROBIA INC (US) | 2009-09-02 | — | — | EP | disclosed |
| US-20090099355-A1 | Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids | MICROBIA, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-20090099355-A1 | Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids | MICROBIA, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-20090099355-A1 | Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids | MICROBIA, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-20080287663-A1 | Process For Production Of 4-Biphenylyazetidin-2-Ones | MICROBIA, INC. (US) | 2008-11-20 | — | — | US | disclosed |
| US-20080287663-A1 | Process For Production Of 4-Biphenylyazetidin-2-Ones | MICROBIA, INC. (US) | 2008-11-20 | — | — | US | disclosed |
| US-20080287663-A1 | Process For Production Of 4-Biphenylyazetidin-2-Ones | MICROBIA, INC. (US) | 2008-11-20 | — | — | US | disclosed |
| US-20080200669-A1 | Processes For Production of Phenolic 4-Biphenylylazetidin-2-Ones | MICROBIA, INC. (US) | 2008-08-21 | — | — | US | disclosed |
| EP-1896135-A2 | PROCESSES FOR PRODUCTION OF 4-(BIPHENYLYL)AZETIDIN-2-ONE PHOSPHONIC ACIDS | Microbia, Inc. (US) | 2008-03-12 | — | — | EP | disclosed |
| EP-1893571-A2 | PROCESS FOR PRODUCTION OF 4-BIPHENYLYAZETIDIN-2-ONES | Microbia Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| EP-1885703-A2 | PROCESSES FOR PRODUCTION OF PHENOLIC 4-BIPHENYLYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006127893-A2 | PROCESSES FOR PRODUCTION OF 4-(BIPHENYLYL)AZETIDIN-2-ONE PHOSPHONIC ACIDS | MICROBIA, INC. (US) | 2006-11-30 | — | — | WO | disclosed |
| WO-2006122020-A2 | PROCESS FOR PRODUCTION OF 4-BIPHENYLYAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2006-11-16 | — | — | WO | disclosed |
| WO-2006122216-A2 | PROCESSES FOR PRODUCTION OF PHENOLIC 4-BIPHENYLYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287663-A1 | Process For Production Of 4-Biphenylyazetidin-2-Ones | CYP4Z1, CYP4F12, CYP4F2 | NPC1 1698/4885RAB9A 1251/4885HTR7 2620/4885 |
| US-20080200669-A1 | Processes For Production of Phenolic 4-Biphenylylazetidin-2-Ones | CYP4B1, CYP4F2, CYP4F12 | NPC1 1948/4885RAB9A 1841/4885HTR7 2167/4885 |
| US-20090099355-A1 | Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids | PIK3CA, PPA1, PIK3CB | NPC1 3374/4885RAB9A 1175/4885HTR7 3640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.