Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 14/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 6/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3852898 | 0.91 | TGFBR1 (0.38) | TGFBR1TGFBR2PRMT5WDR77KCNH2 | |
| Trifluoroacetic Acid SCHEMBL3851547 | 0.91 | TGFBR1 (0.39) | TGFBR1TGFBR2PRMT5WDR77GABRA1 | |
| Trifluoroacetic Acid SCHEMBL3850035 | 0.88 | FYN (0.43) | — | |
| Trifluoroacetic Acid SCHEMBL3849822 | 0.83 | TGFBR1 (0.37) | TGFBR1TGFBR2PRMT5WDR77 | |
| SCHEMBL13874247 | 0.82 | CLK1 (0.40) | TGFBR1TGFBR2PRMT5WDR77KCNH2 | |
| SCHEMBL13874242 | 0.82 | FLT3 (0.45) | TGFBR1PRMT5WDR77KCNH2 | |
| Hydrochloric Acid SCHEMBL3847778 | 0.81 | FLT3 (0.44) | TGFBR1PRMT5WDR77KCNH2 | |
| Trifluoroacetic Acid SCHEMBL3850710 | 0.80 | TGFBR1 (0.36) | TGFBR1TGFBR2MKNK1MKNK2 | |
| Trifluoroacetic Acid SCHEMBL3856637 | 0.79 | TGFBR1 (0.36) | TGFBR1 | |
| Trifluoroacetic Acid SCHEMBL3845848 | 0.79 | FYN (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |