⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23788219 | 0.82 | GSK3B (0.31) | — | |
| SCHEMBL28174928 | 0.82 | MAPT (0.42) | — | |
| SCHEMBL2778839 | 0.78 | — | — | |
| SCHEMBL7204207 | 0.76 | — | — | |
| SCHEMBL1786898 | 0.76 | — | — | |
| SCHEMBL13457827 | 0.73 | — | — | |
| SCHEMBL827117 | 0.71 | — | — | |
| SCHEMBL10293954 | 0.71 | — | — | |
| SCHEMBL8632998 | 0.71 | ALDH1A1 (0.31) | — | |
| SCHEMBL8836807 | 0.71 | GSK3B (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12247004-B2 | 2-amino-N-(amino-oxo-aryl-lambda6-sulfanylidene)acetamide compounds and their therapeutic use | Oxford Drug Design Limited (GB) | 2025-03-11 | — | — | US | disclosed |
| CN-114846000-B | 2-Amino-N- (amino-oxo-aryl-lambda 6-sulfinyl) acetamide compounds and therapeutic uses thereof | 牛津药物设计有限公司 | 2025-01-03 | — | — | CN | disclosed |
| CN-117794527-A | Novel AMP-activating protein kinase activators | 学校法人京都药科大学 | 2024-03-29 | — | — | CN | disclosed |
| US-20230114875-A1 | 2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | Oxford Drug Design Limited (GB) | 2023-04-13 | — | — | US | disclosed |
| EP-4077289-A1 | 2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | Oxford Drug Design Limited (GB) | 2022-10-26 | — | — | EP | disclosed |
| CN-114846000-A | 2-amino-N- (amino-oxo-aryl- λ 6-thioalkyl) acetamide compounds and therapeutic uses thereof | 牛津药物设计有限公司 | 2022-08-02 | — | — | CN | disclosed |
| WO-2021123237-A1 | 2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | Oxford Drug Design Limited (GB) | 2021-06-24 | — | — | WO | disclosed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |
| US-7582589-B2 | comprising a trimethylsily containing substituent on thiophene having microbiocidal activity; against the phytopathogenic fungi: agriculture or horticulture for controlling or preventing infestation of plants | SYNGENTA CROP PROTECTION, INC. (US) | 2009-09-01 | — | — | US | disclosed |
| EP-1620431-B1 | 3-CARBONYLAMINOTHIOPHENES AND THEIR USE AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-08-27 | — | — | EP | disclosed |
| US-20060276434-A1 | 3-Carbonylaminothiophenes and their use as fungicides | SYNGENTA CROP PROTECTION, INC. | 2006-12-07 | — | — | US | disclosed |