Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 16/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857417 | 0.88 | TGFBR1 (0.42) | TGFBR1TGFBR2MKNK1MKNK2CYP2C9 | |
| SCHEMBL3850093 | 0.86 | TGFBR1 (0.46) | TGFBR1TGFBR2MKNK1MKNK2 | |
| SCHEMBL3845587 | 0.84 | TGFBR1 (0.43) | TGFBR1TGFBR2 | |
| SCHEMBL3846170 | 0.83 | TGFBR1 (0.46) | TGFBR1TGFBR2 | |
| SCHEMBL3847225 | 0.83 | TGFBR1 (0.43) | TGFBR1TGFBR2MKNK1MKNK2ATM | |
| SCHEMBL3845039 | 0.81 | TGFBR1 (0.46) | TGFBR1TGFBR2ATM | |
| SCHEMBL3852272 | 0.81 | TGFBR1 (0.41) | TGFBR1TGFBR2MKNK1MKNK2 | |
| SCHEMBL3846841 | 0.81 | TGFBR1 (0.48) | TGFBR1TGFBR2MKNK1MKNK2 | |
| SCHEMBL3846843 | 0.79 | TGFBR1 (0.41) | TGFBR1TGFBR2 | |
| SCHEMBL3847481 | 0.79 | TGFBR1 (0.40) | TGFBR1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |