Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.35 |
| ▸ | CLK1 | P49759 | 4/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3852108 | 0.89 | CYP1A2 (0.39) | METCLK1MAPK1ALDH1A1HPGD | |
| SCHEMBL3848697 | 0.87 | ALDH1A1 (0.45) | METMAPK1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3852747 | 0.86 | ALDH1A1 (0.39) | METCLK1FGFR3KDRFLT3 | |
| SCHEMBL3847806 | 0.84 | TMIGD3 (0.37) | METCLK1MAPK1NPC1RAB9A | |
| SCHEMBL3846961 | 0.84 | TRPV1 (0.47) | METCLK1FGFR3KDR | |
| SCHEMBL3849284 | 0.84 | EPHB3 (0.38) | METCLK1FGFR3KDRMAPK1 | |
| SCHEMBL3847490 | 0.84 | MAPT (0.40) | METCLK1MAPK1FLT3ALDH1A1 | |
| SCHEMBL3847097 | 0.84 | PRMT5 (0.38) | METCLK1FGFR3KDRFLT3 | |
| SCHEMBL3851356 | 0.83 | KDR (0.46) | KDRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3845909 | 0.83 | EPHB3 (0.41) | METNR3C1CLK1FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |