SCHEMBL3855065

SCHEMBL3855065

C[Si](C)(C)c1sccc1NC=O

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19255871 0.74
SCHEMBL11636830 0.71 ALDH1A1 (0.34) ALDH1A1TSHR
SCHEMBL3853535 0.70
SCHEMBL652180 0.69
SCHEMBL13548742 0.69
SCHEMBL3857710 0.69
SCHEMBL2799189 0.66 NPC1 (0.59) ALDH1A1TSHR
SCHEMBL11664361 0.66 KDM5A (0.37) ALDH1A1TSHR
SCHEMBL16413175 0.65 PTPN2 (0.58) ALDH1A1
SCHEMBL7002263 0.64 MAPK8 (0.49) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7582589-B2 comprising a trimethylsily containing substituent on thiophene having microbiocidal activity; against the phytopathogenic fungi: agriculture or horticulture for controlling or preventing infestation of plants SYNGENTA CROP PROTECTION, INC. (US) 2009-09-01 US disclosed
EP-1620431-B1 3-CARBONYLAMINOTHIOPHENES AND THEIR USE AS FUNGICIDES SYNGENTA PARTICIPATIONS AG (CH) 2008-08-27 EP disclosed
US-20060276434-A1 3-Carbonylaminothiophenes and their use as fungicides SYNGENTA CROP PROTECTION, INC. 2006-12-07 US disclosed
EP-1620431-A1 3-CARBONYLAMINOTHIOPHENES AND THEIR USE AS FUNGICIDES Syngenta Participations AG (CH) 2006-02-01 EP disclosed
WO-2004099195-A1 3-CARBONYLAMINOTHIOPHENES AND THEIR USE AS FUNGICIDES SYNGENTA PARTICIPATIONS AG (CH) 2004-11-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060276434-A1 3-Carbonylaminothiophenes and their use as fungicides CBR3, CBR1, HAAO ALDH1A1 988/4885TSHR 1869/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.