Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846170 | 0.91 | TGFBR1 (0.46) | TGFBR1TGFBR2IRAK4 | |
| SCHEMBL3846843 | 0.90 | TGFBR1 (0.41) | TGFBR1TGFBR2 | |
| SCHEMBL3852272 | 0.90 | TGFBR1 (0.41) | TGFBR1TGFBR2 | |
| SCHEMBL3847481 | 0.90 | TGFBR1 (0.40) | TGFBR1TGFBR2 | |
| SCHEMBL3846055 | 0.90 | TGFBR1 (0.42) | TGFBR1TGFBR2 | |
| SCHEMBL3846122 | 0.88 | FYN (0.42) | TGFBR1TGFBR2 | |
| SCHEMBL3854925 | 0.88 | TGFBR1 (0.39) | TGFBR1TGFBR2 | |
| SCHEMBL3847225 | 0.88 | TGFBR1 (0.43) | TGFBR1TGFBR2 | |
| SCHEMBL4712454 | 0.88 | TGFBR1 (0.39) | TGFBR1TGFBR2 | |
| SCHEMBL3849616 | 0.88 | TGFBR1 (0.39) | TGFBR1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |