Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835447 | 0.91 | ATR (0.34) | ATRATRIPNR1H2BRD4CREBBP | |
| SCHEMBL3834957 | 0.90 | ATR (0.38) | ATRATRIPNR1H2BRD4CREBBP | |
| SCHEMBL3840922 | 0.87 | NR1H2 (0.35) | ATRATRIPNR1H2BRD4CREBBP | |
| SCHEMBL3147222 | 0.86 | ATR (0.34) | ATRATRIPNR1H2TBK1IDO1 | |
| SCHEMBL3159477 | 0.85 | ATR (0.34) | ATRATRIPNR1H2BRD4CREBBP | |
| SCHEMBL3163875 | 0.83 | IDO1 (0.33) | ATRATRIPNR1H2BRD4CREBBP | |
| SCHEMBL3840220 | 0.83 | ATR (0.35) | ATRATRIPNR1H2NR1H3 | |
| SCHEMBL3161873 | 0.82 | BRD4 (0.34) | ATRATRIPNR1H2BRD4CREBBP | |
| SCHEMBL3157538 | 0.80 | IDO1 (0.33) | ATRATRIPNR1H2IDO1TDO2 | |
| SCHEMBL3156013 | 0.80 | TBK1 (0.34) | ATRATRIPNR1H2TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |