Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | AKT2 | P31751 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
| ▸ | EIF4E | P06730 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3848455 | 0.93 | MKNK1 (0.38) | TGFBR1MKNK1MKNK2FLT3EIF4E | |
| SCHEMBL3849790 | 0.93 | AKT1 (0.37) | TGFBR1MKNK1MKNK2AKT1AKT2 | |
| SCHEMBL3847207 | 0.89 | MKNK1 (0.35) | TGFBR1MKNK1MKNK2FLT3 | |
| SCHEMBL3845544 | 0.87 | FLT3 (0.44) | TGFBR1MKNK1MKNK2AKT1AKT2 | |
| SCHEMBL3850681 | 0.87 | FLT3 (0.37) | TGFBR1MKNK1MKNK2FLT3 | |
| SCHEMBL3846331 | 0.87 | FYN (0.38) | AKT1AKT2FLT3 | |
| SCHEMBL3853072 | 0.86 | FLT3 (0.49) | TGFBR1AKT1AKT2FLT3 | |
| SCHEMBL3849419 | 0.86 | FLT3 (0.36) | MKNK1MKNK2FLT3 | |
| SCHEMBL3846538 | 0.85 | FLT3 (0.36) | MKNK1MKNK2FLT3ALDH1A1SMN1; SMN2 | |
| SCHEMBL3857422 | 0.85 | PAX8 (0.36) | MKNK1MKNK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |