Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 10/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340771 | 0.78 | CXCR2 (0.43) | CXCR2 | |
| SCHEMBL3343811 | 0.71 | CXCR2 (0.49) | CXCR2 | |
| SCHEMBL3337830 | 0.64 | CXCR2 (0.52) | CXCR2 | |
| SCHEMBL3340936 | 0.63 | CXCR2 (0.48) | CXCR2 | |
| SCHEMBL3337864 | 0.63 | CXCR2 (0.49) | CXCR2 | |
| SCHEMBL3339100 | 0.62 | CXCR2 (0.46) | CXCR2 | |
| SCHEMBL3338299 | 0.61 | CXCR2 (0.52) | CXCR2 | |
| SCHEMBL3340295 | 0.61 | CXCR2 (0.48) | CXCR2 | |
| SCHEMBL3341508 | 0.60 | CXCR2 (0.48) | CXCR2 | |
| SCHEMBL3336608 | 0.60 | CXCR2 (0.48) | CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094697-A1 | 5-SULFANYLMETHYL-PYRAZOLO [1,5-A]PYRIMIDIN-7-OL DERIVATIVES AS CXCR2 ANTAGONISTS | Novartis AG (CH) | 2009-09-02 | — | — | EP | claimed |
| WO-2008062026-A1 | 5-SULFANYLMETHYL-PYRAZOLO [1,5-A] PYRIMIDIN-7-OL DERIVATIVES AS CXCR2 ANTAGONISTS | NOVARTIS AG (CH) | 2008-05-29 | — | — | WO | claimed |