SCHEMBL3856944

SCHEMBL3856944

CCOC(=O)C1c2ccccc2N(C)c2ccccc21

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.55
HDAC7 Q8WUI4 1/20 0.55
HDAC5 Q9UQL6 1/20 0.55
ATM Q13315 1/20 0.47
KMT2A Q03164 5/20 0.45
MEN1 O00255 4/20 0.45
LMNA P02545 2/20 0.45
GAA P10253 2/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
CYP1A2 P05177 2/20 0.44
CHRM2 P08172 1/20 0.44
CYP2D6 P10635 1/20 0.44
CHRM1 P11229 1/20 0.44
KCNH2 Q12809 1/20 0.44
EGFR P00533 2/20 0.43
SRC P12931 1/20 0.43
KDM4E B2RXH2 2/20 0.43
TSHR P16473 2/20 0.43
BCHE P06276 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13005772 0.89 HDAC4 (0.57) HDAC4HDAC7HDAC5ATMKMT2A
SCHEMBL2996947 0.84 HDAC4 (0.53) HDAC4HDAC7HDAC5ATMKMT2A
SCHEMBL15505387 0.84 HDAC4 (0.53) HDAC4HDAC7HDAC5ATMKMT2A
SCHEMBL6276470 0.84 HDAC4 (0.49) HDAC4HDAC7HDAC5KMT2AMEN1
SCHEMBL2992029 0.83 HDAC4 (0.67) HDAC4HDAC7HDAC5KMT2AMEN1
SCHEMBL38661846 0.83 HDAC4 (0.67) HDAC4HDAC7HDAC5KMT2AMEN1
SCHEMBL1075110 0.82 HDAC4 (0.50) HDAC4HDAC7HDAC5ATMKMT2A
SCHEMBL14491000 0.81 HDAC4 (0.60) HDAC4HDAC7HDAC5ATMKMT2A
SCHEMBL7758345 0.81 HDAC4 (0.47) HDAC4HDAC7HDAC5KMT2AMEN1
SCHEMBL1419881 0.80 CYP1A2 (0.55) HDAC4HDAC7HDAC5ATMKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1509601-B1 FLUORESCENT DETECTION OF PEROXIDASE ENZYMES LUMIGEN INC (US) 2012-12-05 EP disclosed
EP-1509601-B1 FLUORESCENT DETECTION OF PEROXIDASE ENZYMES LUMIGEN INC (US) 2012-12-05 EP disclosed
EP-1509601-A4 FLUORESCENT DETECTION OF PEROXIDASE ENZYMES LUMIGEN INC (US) 2009-01-14 EP disclosed
US-6897036-B2 Fluorescent detection of peroxidase enzymes LUMIGEN, INC. (US) 2005-05-24 US disclosed
EP-1509601-A1 FLUORESCENT DETECTION OF PEROXIDASE ENZYMES LUMIGEN, INC. (US) 2005-03-02 EP disclosed
US-20030232405-A1 Fluorescent detection of peroxidase enzymes LUMIGEN INC. 2003-12-18 US disclosed
WO-2003104447-A1 FLUORESCENT DETECTION OF PEROXIDASE ENZYMES LUMIGEN, INC. (US) 2003-12-18 WO disclosed