SCHEMBL7758345

SCHEMBL7758345

CCOC(=S)C1c2ccccc2N(C)c2ccccc21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47
EGFR P00533 2/20 0.40
SRC P12931 1/20 0.40
GAA P10253 2/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
LMNA P02545 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ALOX12 P18054 2/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
KDM4E B2RXH2 1/20 0.37
ACHE P22303 4/20 0.36
BCHE P06276 1/20 0.36
ADRA2A P08913 1/20 0.36
ADRA2B P18089 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acridan SCHEMBL7755720 0.85 ALDH1A1 (0.37) HDAC4HDAC7HDAC5EGFRMEN1
SCHEMBL7026633 0.82 HDAC4 (0.43) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL3856944 0.81 HDAC4 (0.55) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL8331385 0.80 HDAC4 (0.50) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL5161928 0.77 HDAC4 (0.47) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7022667 0.77 HDAC4 (0.44) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL5705606 0.75 HDAC4 (0.56) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7025463 0.74 HDAC4 (0.44) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7755709 0.74 HDAC4 (0.44) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL8740676 0.74 HDAC4 (0.41) HDAC4HDAC7HDAC5EGFRSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0755457-B1 Novel Aryl-N-Alkylacridanthiocarboxylate derivatives useful for chemiluminescent detection LUMIGEN INC (US) 2001-02-21 EP disclosed
EP-0755457-A4 NOVEL ARYL-N-ALKYLACRIDANTHIOCARBOXYLATE DERIVATIVES USEFUL FOR CHEMILUMINESCENT DETECTION LUMIGEN INC (US) 1997-07-16 EP disclosed
EP-0755457-A1 NOVEL ARYL-N-ALKYLACRIDANTHIOCARBOXYLATE DERIVATIVES USEFUL FOR CHEMILUMINESCENT DETECTION LUMIGEN, INC. (US) 1997-01-29 EP disclosed
US-5523212-A OXIDATION WITH PEROXIDE AND PEROXIDASE TO EXCITED ACRIDONE DERIVATIVE; DETECTING PROTEINS, HAPTENS, ANTIBODIES, ENZYMES LUMIGEN, INC. (US) 1996-06-04 US disclosed
WO-1995028495-A1 NOVEL ARYL-N-ALKYLACRIDANTHIOCARBOXYLATE DERIVATIVES USEFUL FOR CHEMILUMINESCENT DETECTION LUMIGEN, INC. (US) 1995-10-26 WO disclosed