Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857149 | 1.00 | GRIK1 (0.55) | GRIK1TBXAS1CYP2C9AKR1C3AKR1C2 | |
| SCHEMBL11335306 | 0.95 | GRIK1 (0.59) | GRIK1TBXAS1CYP2C9AKR1C3AKR1C2 | |
| SCHEMBL321287 | 0.95 | GRIK1 (0.59) | GRIK1TBXAS1CYP2C9AKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL27356431 | 0.93 | GRIK1 (0.58) | GRIK1TBXAS1CYP2C9AKR1C3AKR1C2 | |
| SCHEMBL9061442 | 0.86 | TP53 (0.59) | TBXAS1CYP2C9AKR1C3TP53ALDH1A1 | |
| SCHEMBL5173409 | 0.86 | TBXAS1 (0.58) | GRIK1TBXAS1CYP2C9AKR1C3TP53 | |
| SCHEMBL4606486 | 0.85 | GRIK1 (0.53) | GRIK1TBXAS1CYP2C9AKR1C3AKR1C2 | |
| SCHEMBL4606493 | 0.85 | GRIK1 (0.53) | GRIK1TBXAS1CYP2C9AKR1C3AKR1C2 | |
| SCHEMBL11329444 | 0.81 | GRIK1 (0.56) | GRIK1TBXAS1CYP2C9AKR1C3AKR1C2 | |
| SCHEMBL11329442 | 0.81 | GRIK1 (0.56) | GRIK1TBXAS1CYP2C9AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592373-B2 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-22 | — | — | US | disclosed |
| US-20050267093-A1 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267093-A1 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | MCHR1, MC4R, MCHR2 | GRIK1 2316/4885TBXAS1 3719/4885CYP2C9 4775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.