Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 15/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839139 | 0.89 | NR1H2 (0.38) | NR1H2ATRATRIPPARP1NR1H3 | |
| SCHEMBL3840818 | 0.89 | PARP1 (0.40) | NR1H2PARP1NR1H3BRD4CREBBP | |
| SCHEMBL3840183 | 0.86 | PARP1 (0.37) | NR1H2PARP1NR1H3BRD4CREBBP | |
| SCHEMBL3840586 | 0.86 | NR1H2 (0.36) | NR1H2PARP1NR1H3BRD4CREBBP | |
| SCHEMBL3839418 | 0.85 | NR1H2 (0.35) | NR1H2PARP1NR1H3BRD4CREBBP | |
| SCHEMBL3835054 | 0.85 | NR1H2 (0.37) | NR1H2PARP1NR1H3 | |
| SCHEMBL3839112 | 0.84 | NR1H2 (0.38) | NR1H2NR1H3 | |
| SCHEMBL3835848 | 0.84 | GPR119 (0.37) | NR1H2NR1H3BRD4CREBBP | |
| SCHEMBL3837190 | 0.83 | NR1H2 (0.35) | NR1H2ATRATRIPNR1H3BRD4 | |
| SCHEMBL3835247 | 0.83 | PARP1 (0.37) | NR1H2PARP1NR1H3BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |