Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3199517 | 0.83 | CRHR1 (0.58) | CRHR1PDCD1LG2CD274MEN1KMT2A | |
| SCHEMBL3218680 | 0.80 | CRHR1 (0.48) | CRHR1PDCD1LG2CD274MEN1KMT2A | |
| SCHEMBL3860001 | 0.80 | CRHR1 (0.55) | CRHR1CASR | |
| SCHEMBL3208861 | 0.75 | CRHR1 (0.69) | CRHR1PDCD1LG2CD274ALDH1A1TSHR | |
| SCHEMBL3199522 | 0.75 | CRHR1 (0.51) | CRHR1CASRALDH1A1KDM4E | |
| SCHEMBL2056029 | 0.74 | CRHR1 (0.53) | CRHR1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2056027 | 0.74 | CRHR1 (0.81) | CRHR1CASRMEN1KMT2AALDH1A1 | |
| SCHEMBL3205326 | 0.74 | CRHR1 (0.57) | CRHR1CASR | |
| SCHEMBL3860605 | 0.73 | CRHR1 (0.59) | CRHR1CASR | |
| SCHEMBL4672562 | 0.73 | CRHR1 (0.68) | CRHR1CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2088861-A2 | BENZIMIDAZOLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008051533-A2 | BENZIMIDAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |