Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.31 |
| ▸ | HTR3B | O95264 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.31 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.31 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30718791 | 0.84 | PRKCI (0.38) | DYRK1APRKCIMAP3K14 | |
| SCHEMBL2939393 | 0.84 | PRKCI (0.38) | DYRK1APRKCIMAP3K14 | |
| SCHEMBL104140 | 0.82 | DYRK1A (0.37) | DYRK1AHTR3EHTR3BCHRNA7HTR3A | |
| SCHEMBL4429996 | 0.78 | DYRK1A (0.32) | DYRK1APRKCIHTR3EHTR3BCHRNA7 | |
| SCHEMBL434678 | 0.75 | CTNNB1 (0.40) | DYRK1APRKCIKCNH2 | |
| SCHEMBL18527086 | 0.73 | DYRK1A (0.39) | DYRK1APRKCI | |
| SCHEMBL10555583 | 0.70 | ALDH1A1 (0.36) | DYRK1A | |
| SCHEMBL16682691 | 0.69 | DYRK1A (0.35) | DYRK1APRKCIMAP3K14 | |
| Hydrochloric Acid SCHEMBL18187528 | 0.68 | DYRK1A (0.34) | DYRK1APRKCI | |
| SCHEMBL103867 | 0.66 | NOTUM (0.44) | CHRNA7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137195-A1 | TRICYCLIC NITROGEN CONTAINING HETEROCYCLES AS ANTIBACTERIAL AGENTS | Glaxo Group Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| EP-2044077-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | Glaxo Group Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008128953-A1 | TRICYCLIC NITROGEN CONTAINING HETEROCYCLES AS ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008009700-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |