Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.53 |
| ▸ | PHF8 | Q9UPP1 | 7/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | KDM5C | P41229 | 4/20 | 0.50 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.48 |
| ▸ | KDM6B | O15054 | 2/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.41 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL3710655 | 1.00 | EGLN1 (0.53) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Sarcosine SCHEMBL28259932 | 0.91 | — | — | |
| Sarcosine SCHEMBL156329 | 0.91 | LDHA (0.44) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Sarcosine SCHEMBL31427574 | 0.91 | — | — | |
| Sarcosine SCHEMBL149 | 0.91 | — | — | |
| Sarcosine SCHEMBL26641423 | 0.91 | LDHA (0.44) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Glutarate SCHEMBL31329219 | 0.89 | SLC22A6 (0.58) | LMNAOR51E2SLC22A6TSHRNFKB1 | |
| Alpha-Ketoglutaric Acid SCHEMBL28776607 | 0.88 | EGLN1 (0.64) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Sarcosine SCHEMBL23041026 | 0.88 | — | — | |
| Sarcosine SCHEMBL4649404 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7537656-B2 | Cement compositions comprising biodegradable monomers for retarding the setting thereof | HALLIBURTON ENERGY SERVICES, INC. (US) | 2009-05-26 | — | — | US | claimed |
| US-7350574-B2 | Methods of retarding the setting of a cement composition using biodegradable monomers | HALLIBURTON ENERGY SERVICES, INC. (US) | 2008-04-01 | — | — | US | claimed |
| US-7537656-B2 | Cement compositions comprising biodegradable monomers for retarding the setting thereof | HALLIBURTON ENERGY SERVICES, INC. (US) | 2009-05-26 | — | — | US | disclosed |
| US-7350574-B2 | Methods of retarding the setting of a cement composition using biodegradable monomers | HALLIBURTON ENERGY SERVICES, INC. (US) | 2008-04-01 | — | — | US | disclosed |
| US-20060288910-A1 | Cement compositions comprising biodegradable monomers for retarding the setting thereof | HALLIBURTON ENERGY SERVICES, INC. | 2006-12-28 | — | — | US | disclosed |
| US-20060289162-A1 | Methods of retarding the setting of a cement composition using biodegradable monomers | HALLIBURTON ENERGY SERVICES, INC. | 2006-12-28 | — | — | US | disclosed |