Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3859836 | 1.00 | ADAM17 (0.88) | ADAM17 | |
| SCHEMBL8270892 | 0.94 | ADAM17 (1.00) | ADAM17 | |
| SCHEMBL3860237 | 0.90 | ADAM17 (0.87) | ADAM17 | |
| SCHEMBL3864322 | 0.90 | ADAM17 (0.88) | ADAM17 | |
| SCHEMBL8270898 | 0.89 | ADAM17 (1.00) | ADAM17 | |
| SCHEMBL3866318 | 0.85 | ADAM17 (0.87) | ADAM17 | |
| SCHEMBL3864303 | 0.84 | ADAM17 (0.86) | ADAM17 | |
| SCHEMBL3864300 | 0.84 | ADAM17 (0.86) | ADAM17 | |
| SCHEMBL3864294 | 0.84 | ADAM17 (0.86) | ADAM17 | |
| SCHEMBL3869314 | 0.84 | ADAM17 (0.90) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595327-B2 | Exo-N-Hydroxy-3-[methyl({4-[(2-methylquinolin-4-yl) methoxy]phenyl}sulfonyl)amino]bicyclo[2.2.1]heptane-2-carboxamide; rheumatoid arthritis (RA), juvenile RA, psoriatic arthritis, ankylosing spondylitis, psoriasis, osteoarthritis, tumor metastasis, sepsis, AIDS, ulcerative colitis, multiple sclerosis | WYETH (US) | 2009-09-29 | — | — | US | disclosed |