Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3863050 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2TP53GAACCR5RAB9A | |
| SCHEMBL1665342 | 0.84 | HCAR2 (0.49) | SMN1; SMN2GAARAB9ATSHRHSD17B10 | |
| SCHEMBL1665343 | 0.81 | TAAR1 (0.53) | SMN1; SMN2GAARAB9AALDH1A1MAPT | |
| SCHEMBL14398956 | 0.76 | HSD17B10 (0.47) | SMN1; SMN2GAARAB9AALDH1A1NPC1 | |
| SCHEMBL3858877 | 0.76 | GAA (0.54) | SMN1; SMN2GAARAB9AALDH1A1NPC1 | |
| SCHEMBL3866711 | 0.76 | GAA (0.54) | SMN1; SMN2GAARAB9AALDH1A1NPC1 | |
| SCHEMBL6201226 | 0.76 | GAA (0.54) | SMN1; SMN2GAARAB9AALDH1A1NPC1 | |
| SCHEMBL6201220 | 0.76 | GAA (0.54) | SMN1; SMN2GAARAB9AALDH1A1NPC1 | |
| SCHEMBL13685721 | 0.74 | PREP (0.44) | SMN1; SMN2GAARAB9AALDH1A1NPC1 | |
| SCHEMBL3863056 | 0.74 | PREP (0.44) | SMN1; SMN2GAARAB9AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592467-B2 | Inhibitors of prolyl endopeptidase | PROBIODRUG AG (DE) | 2009-09-22 | — | — | US | disclosed |
| EP-1869008-A1 | INHIBITORS OF PROLYL ENDOPEPTIDASE | Probiodrug AG (DE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006120104-A1 | INHIBITORS OF PROLYL ENDOPEPTIDASE | PROBIODRUG AG (DE) | 2006-11-16 | — | — | WO | disclosed |
| US-20060229357-A1 | Compounds | PROBIODRUG AG | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229357-A1 | Compounds | PREP, BACE1, MME | SMN1; SMN2 2034/4885TP53 1331/4885GAA 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.