Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.70 |
| ▸ | EGFR | P00533 | 13/20 | 0.70 |
| ▸ | RET | P07949 | 3/20 | 0.70 |
| ▸ | KIF5B | P33176 | 2/20 | 0.70 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.70 |
| ▸ | FLT1 | P17948 | 11/20 | 0.70 |
| ▸ | FLT4 | P35916 | 10/20 | 0.70 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.70 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.70 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.70 |
| ▸ | TEK | Q02763 | 2/20 | 0.70 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.70 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.70 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.70 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.70 |
| ▸ | PLK4 | O00444 | 1/20 | 0.70 |
| ▸ | CIT | O14578 | 1/20 | 0.70 |
| ▸ | GAK | O14976 | 1/20 | 0.70 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5458741 | 0.90 | KDR (0.75) | KDREGFRRETKIF5BFGFR1 | |
| Hydrochloric Acid SCHEMBL157862 | 0.89 | KDR (0.77) | KDREGFRRETKIF5BFGFR1 | |
| SCHEMBL16085055 | 0.84 | EGFR (0.84) | KDREGFRRETKIF5BFGFR1 | |
| SCHEMBL1657315 | 0.84 | EGFR (0.83) | KDREGFRRETKIF5BFGFR1 | |
| SCHEMBL5864525 | 0.84 | KDR (1.00) | KDREGFRRETKIF5BFGFR1 | |
| Hydrochloric Acid SCHEMBL7864775 | 0.83 | KDR (0.98) | KDREGFRRETKIF5BFGFR1 | |
| Vandetanib SCHEMBL9044 | 0.82 | EGFR (1.00) | KDREGFRRETKIF5BFGFR1 | |
| Vandetanib SCHEMBL29352879 | 0.82 | EGFR (1.00) | KDREGFRRETKIF5BFGFR1 | |
| Vandetanib SCHEMBL28224661 | 0.82 | EGFR (1.00) | KDREGFRRETKIF5BFGFR1 | |
| SCHEMBL20343335 | 0.82 | EGFR (0.80) | KDREGFRRETKIF5BFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541027-B2 | Use of an epitope of vascular endothelial growth factor receptor KDR/Flk-1 | ASTRAZENECA AB (SE) | 2009-06-02 | — | — | US | disclosed |
| US-20050221317-A1 | Use of an epitope of vascular endothelial growth factor receptor kdr/flk-1 | ASTRAZENECA AB (SE) | 2005-10-06 | — | — | US | disclosed |
| EP-1487876-A1 | THE USE OF AN EPITOPE OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR KDR/FLK-1 | Astrazeneca AB (SE) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078465-A1 | THE USE OF AN EPITOPE OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR KDR/FLK-1 | ASTRAZENECA AB (SE) | 2003-09-25 | — | — | WO | disclosed |