SCHEMBL3864150

SCHEMBL3864150

CCCc1nc2c(N)nc3cc(Br)ccc3c2n1CCCCNC(=O)NC(C)C

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 17/20 0.52
TLR8 Q9NR97 8/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3865895 0.89 TLR7 (0.54) TLR7TLR8
SCHEMBL3873650 0.89 TLR7 (0.56) TLR7TLR8
SCHEMBL544696 0.88 TLR7 (0.60) TLR7TLR8
SCHEMBL3862047 0.85 TLR7 (0.51) TLR7TLR8
SCHEMBL6107851 0.84 TLR7 (0.47) TLR7TLR8
SCHEMBL3864126 0.82 TLR7 (0.65) TLR7TLR8
SCHEMBL5618076 0.82 TLR7 (0.54) TLR7TLR8
SCHEMBL3861868 0.82 TLR7 (0.66) TLR7TLR8
SCHEMBL3162703 0.81 TLR7 (0.53) TLR7TLR8
SCHEMBL6246533 0.81 TLR7 (0.55) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2103299-B1 Oxidizing hair colourant compositions PROCTER & GAMBLE (US) 2013-02-27 EP claimed
US-7597720-B2 Oxidizing hair colourant compositions THE PROCTER & GAMBLE COMPANY (US) 2009-10-06 US claimed
EP-2103299-A2 Oxidizing hair colourant compositions The Procter and Gamble Company (US) 2009-09-23 EP claimed
US-20090119852-A1 Oxidizing Hair Colourant Compositions WELLA OPERATIONS US, LLC 2009-05-14 US claimed
WO-2009060334-A2 OXIDIZING HAIR COLOURANT COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2009-05-14 WO claimed
US-7598382-B2 Aryl substituted imidazoquinolines COLEY PHARMACEUTICAL GROUP, INC. (US) 2009-10-06 US disclosed
US-7091214-B2 Aryl substituted Imidazoquinolines 3M INNOVATIVE PROPERTIES CO. (US) 2006-08-15 US disclosed
US-20060111387-A1 ARYL SUBSTITUTED IMIDAZOQUINOLINES 3M INNOVATIVE PROPERTIES COMPANY 2006-05-25 US disclosed
EP-1590348-A1 ARYL / HETARYL SUBSTITUTED IMIDAZOQUINOLINES 3M Innovative Properties Company (US) 2005-11-02 EP disclosed
US-20040147543-A1 Aryl substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2004-07-29 US disclosed
WO-2004058759-A1 ARYL / HETARYL SUBSTITUTED IMIDAZOQUINOLINES 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-07-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090119852-A1 Oxidizing Hair Colourant Compositions TET1, TET2, TET3 TLR7 3449/4885TLR8 2799/4885
US-20040147543-A1 Aryl substituted imidazoquinolines IL2, IFNG, IRF3 TLR7 68/4885TLR8 220/4885
US-20060111387-A1 ARYL SUBSTITUTED IMIDAZOQUINOLINES IL2, IFNG, IRF3 TLR7 68/4885TLR8 220/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.