Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270885 | 1.00 | ADAM17 (1.00) | ADAM17 | |
| SCHEMBL8270882 | 0.93 | ADAM17 (1.00) | ADAM17 | |
| SCHEMBL3859878 | 0.93 | ADAM17 (1.00) | ADAM17 | |
| SCHEMBL3860774 | 0.92 | ADAM17 (0.86) | ADAM17 | |
| SCHEMBL3869338 | 0.91 | ADAM17 (0.83) | ADAM17 | |
| SCHEMBL3859576 | 0.87 | ADAM17 (1.00) | ADAM17 | |
| SCHEMBL3861035 | 0.87 | ADAM17 (1.00) | ADAM17 | |
| SCHEMBL3859797 | 0.87 | ADAM17 (1.00) | ADAM17 | |
| SCHEMBL3859743 | 0.87 | ADAM17 (0.79) | ADAM17 | |
| SCHEMBL3859799 | 0.87 | ADAM17 (1.00) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595327-B2 | Exo-N-Hydroxy-3-[methyl({4-[(2-methylquinolin-4-yl) methoxy]phenyl}sulfonyl)amino]bicyclo[2.2.1]heptane-2-carboxamide; rheumatoid arthritis (RA), juvenile RA, psoriatic arthritis, ankylosing spondylitis, psoriasis, osteoarthritis, tumor metastasis, sepsis, AIDS, ulcerative colitis, multiple sclerosis | WYETH (US) | 2009-09-29 | — | — | US | claimed |
| US-7595327-B2 | Exo-N-Hydroxy-3-[methyl({4-[(2-methylquinolin-4-yl) methoxy]phenyl}sulfonyl)amino]bicyclo[2.2.1]heptane-2-carboxamide; rheumatoid arthritis (RA), juvenile RA, psoriatic arthritis, ankylosing spondylitis, psoriasis, osteoarthritis, tumor metastasis, sepsis, AIDS, ulcerative colitis, multiple sclerosis | WYETH (US) | 2009-09-29 | — | — | US | disclosed |