Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.65 |
| ▸ | TSHR | P16473 | 5/20 | 0.65 |
| ▸ | SLC9A1 | P19634 | 4/20 | 0.65 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | RAD52 | P43351 | 1/20 | 0.63 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SLC9A5 | Q14940 | 6/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11616169 | 0.83 | CYP1A2 (0.61) | CYP1A2TSHRSLC9A1FTOCYP3A4 | |
| SCHEMBL2432734 | 0.80 | CYP1A2 (0.70) | CYP1A2TSHRSLC9A1FTOCYP3A4 | |
| SCHEMBL13377995 | 0.79 | TSHR (0.41) | CYP1A2TSHRSLC9A1FTOCYP3A4 | |
| SCHEMBL29406659 | 0.79 | CYP1A2 (1.00) | CYP1A2TSHRSLC9A1FTOCYP3A4 | |
| SCHEMBL9852481 | 0.79 | CYP1A2 (1.00) | CYP1A2TSHRSLC9A1FTOCYP3A4 | |
| SCHEMBL3793535 | 0.78 | TDP1 (0.57) | CYP1A2TSHRSLC9A1FTOCYP3A4 | |
| SCHEMBL29768708 | 0.78 | TDP1 (0.57) | CYP1A2TSHRSLC9A1FTOCYP3A4 | |
| SCHEMBL11528396 | 0.78 | CYP1A2 (0.68) | CYP1A2TSHRSLC9A1FTOCYP3A4 | |
| SCHEMBL14513863 | 0.78 | CYP1A2 (0.81) | CYP1A2TSHRSLC9A1FTOCYP3A4 | |
| SCHEMBL11528389 | 0.77 | CYP1A2 (0.58) | CYP1A2TSHRSLC9A1FTOCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1715867-A4 | BIPYRIDYL AMIDES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2009-04-15 | — | — | EP | disclosed |
| US-20070149547-A1 | Bipyridyl amides as modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-06-28 | — | — | US | disclosed |
| CN-1933838-A | Bipyridyl amides as modulators of metabotropic glutamate receptor-5 | MERCK & CO INC (US) | 2007-03-21 | — | — | CN | disclosed |
| EP-1715867-A1 | BIPYRIDYL AMIDES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Merck & Co., Inc. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005079802-A1 | BIPYRIDYL AMIDES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149547-A1 | Bipyridyl amides as modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GABRA5 | CYP1A2 1905/4885TSHR 675/4885SLC9A1 3200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.