Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.76 |
| ▸ | AURKA | O14965 | 3/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| R-112 SCHEMBL655935 | 0.87 | SYK (1.00) | SYKAURKAMAPK8AURKBCDK19 | |
| R-112 SCHEMBL29360016 | 0.87 | SYK (1.00) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL27631427 | 0.87 | SYK (0.74) | SYKAURKAMAPK8AURKBCDK19 | |
| R-112 SCHEMBL31294216 | 0.87 | SYK (1.00) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL654694 | 0.85 | SYK (0.72) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL656495 | 0.81 | SYK (0.87) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL657334 | 0.81 | SYK (0.87) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL27612598 | 0.80 | SYK (0.85) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL12567975 | 0.80 | SYK (0.85) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL658886 | 0.79 | SYK (0.74) | SYKAURKAMAPK8AURKBCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589200-B2 | 5-Fluoro-4N-phenyl-4-pyrimidineamine compounds | RIGEL PHARMACEUTICALS, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-20050209230-A1 | 2-leaving group-4-(substituted amino)-5-fluoropyrimidines such as 2-chloro-N4-(2-hydroxyphenyl)-5-fluoro-4-pyrimidineamine; chemical intermediates to compounds that inhibit the immunoglobulin (Ig) IgE and/or IgG receptor signaling cascades | MIDCAP FINANCIAL TRUST | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209230-A1 | 2-leaving group-4-(substituted amino)-5-fluoropyrimidines such as 2-chloro-N4-(2-hydroxyphenyl)-5-fluoro-4-pyrimidineamine; chemical intermediates to compounds that inhibit the immunoglobulin (Ig) IgE and/or IgG receptor signaling cascades | FCER2, FCGR1A, FCGR2A | SYK 42/4885AURKA 1583/4885MAPK8 1172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.