Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL488612 | 0.79 | AURKA (0.49) | DYRK1APIM1LRRK2AURKADAPK3 | |
| SCHEMBL15631658 | 0.75 | DYRK1A (0.39) | DYRK1APIM1LRRK2AURKADAPK3 | |
| SCHEMBL2576926 | 0.72 | DYRK1A (0.46) | DYRK1APIM1LRRK2AURKADAPK3 | |
| SCHEMBL31046993 | 0.72 | DYRK1A (0.46) | DYRK1APIM1LRRK2AURKADAPK3 | |
| SCHEMBL25868526 | 0.68 | DYRK1A (0.49) | DYRK1APIM1LRRK2AURKADAPK3 | |
| SCHEMBL14895222 | 0.68 | DYRK1A (0.62) | DYRK1APIM1LRRK2AURKADAPK3 | |
| SCHEMBL19897476 | 0.68 | PARP1 (0.46) | AURKANOS1KDM4EALDH1A1OGT | |
| SCHEMBL1500233 | 0.68 | METAP2 (0.43) | DYRK1APIM1LRRK2AURKADAPK3 | |
| SCHEMBL17032390 | 0.66 | CCR1 (0.41) | DYRK1ANOS1NOS3NOS2KDM4E | |
| SCHEMBL24002739 | 0.66 | AURKA (0.46) | DYRK1APIM1LRRK2AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097416-A1 | AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | Amgen, Inc (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008076425-A1 | AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2008-06-26 | — | — | WO | disclosed |