SCHEMBL38659652

SCHEMBL38659652

N#C/C(=C\c1ccc(-c2cc(Cl)ccc2Cl)o1)C(=O)Nc1ccc(C(F)(F)F)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.64
TP53 P04637 3/20 0.64
BLM P54132 1/20 0.64
THRB P10828 3/20 0.63
SIRT5 Q9NXA8 4/20 0.59
SIRT2 Q8IXJ6 3/20 0.59
MTOR P42345 1/20 0.59
SIRT1 Q96EB6 1/20 0.59
SIRT3 Q9NTG7 1/20 0.59
SMN1; SMN2 Q16637 4/20 0.56
LMNA P02545 3/20 0.56
POLB P06746 3/20 0.56
KMT2A Q03164 5/20 0.52
NPC1 O15118 4/20 0.52
RAB9A P51151 4/20 0.52
MEN1 O00255 4/20 0.52
TDP1 Q9NUW8 2/20 0.52
ATM Q13315 1/20 0.52
PTPN1 P18031 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL38659253 0.88 MAPT (0.77) MAPTTP53BLMTHRBSIRT5
SCHEMBL38661254 0.87 MAPT (0.56) MAPTTP53BLMTHRBSIRT5
SCHEMBL38660794 0.85 MAPT (0.64) MAPTTP53BLMTHRBSIRT5
SCHEMBL38660339 0.84 MAPT (0.61) MAPTTP53BLMTHRBSIRT5
SCHEMBL38663467 0.81 TP53 (0.57) MAPTTP53BLMTHRBSIRT5
SCHEMBL38660147 0.81 MAPT (0.62) MAPTTP53BLMTHRBSIRT5
SCHEMBL38661148 0.81 MAPT (0.64) MAPTTP53BLMTHRBSIRT5
SCHEMBL2845367 0.81 TP53 (0.51) MAPTTP53BLMTHRBSIRT5
SCHEMBL2845364 0.81 TP53 (0.51) MAPTTP53BLMTHRBSIRT5
SCHEMBL18087601 0.80 MEN1 (0.72) MAPTTP53BLMTHRBSIRT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026101221-A1 NOVEL COMPOUND 아주대학교 산학협력단 2026-05-15 WO disclosed