Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.72 |
| ▸ | POLB | P06746 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.72 |
| ▸ | SIRT5 | Q9NXA8 | 7/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | EP300 | Q09472 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18084859 | 0.85 | MEN1 (0.64) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL38659253 | 0.83 | MAPT (0.77) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL38659652 | 0.80 | MAPT (0.64) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL38660794 | 0.78 | MAPT (0.64) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL28376708 | 0.78 | SIRT5 (0.84) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL38664303 | 0.77 | MAPT (0.58) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL28371840 | 0.77 | SIRT5 (1.00) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL28371417 | 0.76 | SIRT5 (1.00) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL38660339 | 0.76 | MAPT (0.61) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL28376807 | 0.75 | SIRT5 (0.78) | MEN1KMT2APOLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180117043-A1 | USE OF SRC PROTEIN INHIBITOR IN THE MANUFACTURE OF A MEDICAMENT FOR THE PROPHYLAXIS AND/OR TREATMENT OF ALZHEIMER'S DISEASE | JENKEM TECHNOLOGY CO., LTD. (BEIJING) (CN) | 2018-05-03 | — | — | US | disclosed |
| US-9834530-B2 | 3-furyl-2-cyano-2-acrylamide derivative, preparation method therefor, pharmaceutical composition and use thereof | JENKEM TECHNOLOGY CO., LTD. (BEIJING) (CN) | 2017-12-05 | — | — | US | disclosed |
| EP-3078659-B1 | 3-FURYL-2-CYANO-2-ACRYLAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | JENKEM TECH CO LTD (BEIJING) (CN) | 2017-11-15 | — | — | EP | disclosed |
| EP-3078659-A1 | 3-FURYL-2-CYANO-2-ACRYLAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Jenkem Technology Co. Ltd. (Beijing) (CN) | 2016-10-12 | — | — | EP | disclosed |
| US-20160272604-A1 | 3-FURYL-2-CYANO-2-ACRYLAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | JENKEM TECHNOLOGY CO., LTD. (BEIJING) (CN) | 2016-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180117043-A1 | USE OF SRC PROTEIN INHIBITOR IN THE MANUFACTURE OF A MEDICAMENT FOR THE PROPHYLAXIS AND/OR TREATMENT OF ALZHEIMER'S DISEASE | SRC, FYN, CALM1 | MEN1 4625/4885KMT2A 1504/4885POLB 3951/4885 |
| US-20160272604-A1 | 3-FURYL-2-CYANO-2-ACRYLAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | EGFR, ERBB2, ERBB3 | MEN1 2035/4885KMT2A 4545/4885POLB 3690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.