Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | OGG1 | O15527 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 4/20 | 0.34 |
| ▸ | CASP1 | P29466 | 3/20 | 0.34 |
| ▸ | CASP7 | P55210 | 3/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 3/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.33 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.33 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3866126 | 1.00 | P2RX3 (0.49) | P2RX3ADAMTS4ADAMTS5ALDH1A1KDM4E | |
| SCHEMBL3866128 | 1.00 | P2RX3 (0.49) | P2RX3ADAMTS4ADAMTS5ALDH1A1KDM4E | |
| SCHEMBL1307398 | 0.90 | P2RX3 (0.51) | P2RX3ADAMTS4ADAMTS5ALDH1A1KDM4E | |
| SCHEMBL1307393 | 0.90 | P2RX3 (0.51) | P2RX3ADAMTS4ADAMTS5ALDH1A1KDM4E | |
| SCHEMBL1307396 | 0.90 | P2RX3 (0.51) | P2RX3ADAMTS4ADAMTS5ALDH1A1KDM4E | |
| SCHEMBL17043085 | 0.89 | P2RX3 (0.49) | P2RX3ADAMTS4ADAMTS5ALDH1A1KDM4E | |
| SCHEMBL17043083 | 0.89 | P2RX3 (0.49) | P2RX3ADAMTS4ADAMTS5ALDH1A1KDM4E | |
| SCHEMBL3821057 | 0.89 | P2RX3 (0.49) | P2RX3ADAMTS4ADAMTS5ALDH1A1KDM4E | |
| SCHEMBL1308802 | 0.89 | P2RX3 (0.54) | P2RX3ADAMTS4ADAMTS5ALDH1A1KDM4E | |
| SCHEMBL1308805 | 0.89 | P2RX3 (0.54) | P2RX3ADAMTS4ADAMTS5ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2913322-A2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | Korea Research Institute Of Chemical Technology (KR) | 2015-09-02 | — | — | EP | disclosed |
| EP-2089354-A1 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Korea Research Institute Of Chemical Technology (KR) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008054154-A1 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-05-08 | — | — | WO | disclosed |