Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.56 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | FES | P07332 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.56 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | BMX | P51813 | 1/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.56 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3824942 | 0.92 | LCK (0.57) | LCKTNK2MAP4K2SRCKDR | |
| SCHEMBL3824576 | 0.84 | TNK2 (0.63) | LCKTNK2MAP4K2ABL1FES | |
| SCHEMBL3829420 | 0.83 | LCK (0.55) | LCKTNK2MAP4K2ABL1SRC | |
| SCHEMBL3832093 | 0.82 | SRC (0.54) | LCKTNK2MAP4K2ABL1SRC | |
| SCHEMBL3824938 | 0.81 | LCK (0.52) | LCKTNK2MAP4K2ABL1SRC | |
| SCHEMBL3831868 | 0.80 | RAF1 (0.59) | RAF1BRAF | |
| SCHEMBL3135890 | 0.80 | TNK2 (0.76) | LCKTNK2MAP4K2ABL1FES | |
| SCHEMBL3827892 | 0.79 | TNK2 (0.56) | LCKTNK2MAP4K2ABL1FES | |
| SCHEMBL3825076 | 0.79 | LCK (0.49) | LCKSRCKDRMAPK14RAF1 | |
| SCHEMBL3832068 | 0.78 | LCK (0.49) | LCKSRCKDRMAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | claimed |
| JP-2007500725-A | — | — | 2007-01-18 | — | — | JP | claimed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | claimed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | claimed |