Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | RORA | P35398 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | RORB | Q92753 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2385054 | 0.87 | MAPT (0.46) | KDM4EAPAF1MAPTPKMIDO1 | |
| SCHEMBL3443882 | 0.86 | KDM4E (0.43) | KDM4EAPAF1MAPTPKMIDO1 | |
| SCHEMBL2382248 | 0.86 | MAPT (0.43) | KDM4EAPAF1MAPTPKMIDO1 | |
| SCHEMBL2386185 | 0.86 | MAOB (0.43) | KDM4EAPAF1MAPTPKMIDO1 | |
| Hydrochloric Acid SCHEMBL3444526 | 0.85 | KDM4E (0.42) | KDM4EAPAF1MAPTPKMIDO1 | |
| SCHEMBL3866299 | 0.85 | HSD17B10 (0.44) | HSD17B10KDM4EMAPTHTTPOLB | |
| SCHEMBL3443894 | 0.85 | CYP2A6 (0.44) | KDM4EAPAF1MAPTPKMIDO1 | |
| SCHEMBL5739997 | 0.84 | KDM4E (0.41) | KDM4EAPAF1MAPTPKMIDO1 | |
| SCHEMBL2384414 | 0.84 | PADI4 (0.44) | HSD17B10KDM4EAPAF1MAPTPKM | |
| SCHEMBL2385267 | 0.84 | KDM4E (0.43) | KDM4EAPAF1MAPTPKMIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524857-B2 | Pharmaceutical combinations based on pyridoindolone derivatives and anticancer agents | SANOFI-AVENTIS (FR) | 2009-04-28 | — | — | US | claimed |
| US-7160895-B2 | Use of pyridoindolone derivatives for the preparation of medicinal products | SANOFI-AVENTIS (FR) | 2007-01-09 | — | — | US | claimed |
| EP-1385513-B1 | PHARMACEUTICAL COMBINATIONS BASED ON PYRIDOINDOLONE DERIVATIVES AND ANTICANCER AGENTS | SANOFI AVENTIS (FR) | 2006-09-06 | — | — | EP | claimed |
| EP-1385512-B1 | USE OF PYRIDOINDOLONE DERIVATIVES FOR PREPARING ANTICANCER MEDICINES | SANOFI AVENTIS (FR) | 2005-12-28 | — | — | EP | claimed |
| US-20050272760-A1 | Use of pyridoindolone derivatives for the preparation of medicinal products | SANOFI-AVENTIS (FR) | 2005-12-08 | — | — | US | claimed |
| US-6967203-B2 | Use of pyridoindolone derivatives for preparing anticancer medicines | SANOFI-AVENTIS (FR) | 2005-11-22 | — | — | US | claimed |
| US-20040122027-A1 | Use of pyridoindolone derivatives for preparing anticancer medicines | SANOFI (FR) | 2004-06-24 | — | — | US | claimed |
| US-20040122036-A1 | Pharmaceutical combinations based on pyridoindolone derivatives and anticancer agents | SANOFI (FR) | 2004-06-24 | — | — | US | claimed |
| EP-1385512-A2 | USE OF PYRIDOINDOLONE DERIVATIVES FOR PREPARING ANTICANCER MEDICINES | Sanofi-Aventis (FR) | 2004-02-04 | — | — | EP | claimed |
| EP-1385513-A1 | PHARMACEUTICAL COMBINATIONS BASED ON PYRIDOINDOLONE DERIVATIVES AND ANTICANCER AGENTS | Sanofi-Aventis (FR) | 2004-02-04 | — | — | EP | claimed |
| WO-2002087574-A2 | USE OF PYRIDOINDOLONE DERIVATIVES FOR PREPARING ANTICANCER MEDICINES | SANOFI-SYNTHELABO (FR) | 2002-11-07 | — | — | WO | claimed |
| WO-2002087575-A1 | PHARMACEUTICAL COMBINATIONS BASED ON PYRIDOINDOLONE DERIVATIVES AND ANTICANCER AGENTS | SANOFI-SYNTHELABO (FR) | 2002-11-07 | — | — | WO | claimed |
| US-7812165-B2 | 6-substituted pyridoindolone derivatives, production and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2010-10-12 | — | — | US | disclosed |
| US-7524857-B2 | Pharmaceutical combinations based on pyridoindolone derivatives and anticancer agents | SANOFI-AVENTIS (FR) | 2009-04-28 | — | — | US | disclosed |
| US-7160895-B2 | Use of pyridoindolone derivatives for the preparation of medicinal products | SANOFI-AVENTIS (FR) | 2007-01-09 | — | — | US | disclosed |
| EP-1385513-B1 | PHARMACEUTICAL COMBINATIONS BASED ON PYRIDOINDOLONE DERIVATIVES AND ANTICANCER AGENTS | SANOFI AVENTIS (FR) | 2006-09-06 | — | — | EP | disclosed |
| EP-1385512-A2 | USE OF PYRIDOINDOLONE DERIVATIVES FOR PREPARING ANTICANCER MEDICINES | Sanofi-Aventis (FR) | 2004-02-04 | — | — | EP | disclosed |
| EP-1385513-A1 | PHARMACEUTICAL COMBINATIONS BASED ON PYRIDOINDOLONE DERIVATIVES AND ANTICANCER AGENTS | Sanofi-Aventis (FR) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002087575-A1 | PHARMACEUTICAL COMBINATIONS BASED ON PYRIDOINDOLONE DERIVATIVES AND ANTICANCER AGENTS | SANOFI-SYNTHELABO (FR) | 2002-11-07 | — | — | WO | disclosed |
| WO-2002087574-A2 | USE OF PYRIDOINDOLONE DERIVATIVES FOR PREPARING ANTICANCER MEDICINES | SANOFI-SYNTHELABO (FR) | 2002-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272760-A1 | Use of pyridoindolone derivatives for the preparation of medicinal products | DPYD, PNPO, ENTPD5 | HSD17B10 1238/4885KDM4E 3484/4885APAF1 2072/4885 |
| US-20040122036-A1 | Pharmaceutical combinations based on pyridoindolone derivatives and anticancer agents | DPYD, DHFR, PNPO | HSD17B10 763/4885KDM4E 3327/4885APAF1 569/4885 |
| US-20040122027-A1 | Use of pyridoindolone derivatives for preparing anticancer medicines | DPYD, PNPO, TYMP | HSD17B10 1176/4885KDM4E 3148/4885APAF1 1860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.