Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 18/20 | 0.79 |
| ▸ | ADORA1 | P30542 | 12/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8245876 | 0.88 | ADORA2A (1.00) | ADORA2AADORA1TSHRKDM4EMEN1 | |
| SCHEMBL3869262 | 0.82 | ADORA2A (1.00) | ADORA2AADORA1TSHRADORA3 | |
| SCHEMBL3869221 | 0.81 | ADORA2A (1.00) | ADORA2AADORA1TSHRPOLB | |
| SCHEMBL16440392 | 0.79 | ADORA2A (0.73) | ADORA2AADORA1TSHRKDM4EMEN1 | |
| SCHEMBL3878528 | 0.77 | ADORA2A (1.00) | ADORA2AADORA1TSHR | |
| SCHEMBL3869046 | 0.77 | ADORA2A (1.00) | ADORA2AADORA1ADORA3 | |
| SCHEMBL1256076 | 0.77 | ADORA2A (0.69) | ADORA2AADORA1TSHRKDM4EMEN1 | |
| SCHEMBL16437807 | 0.76 | ADORA2A (0.68) | ADORA2AADORA1TSHRKDM4EMEN1 | |
| SCHEMBL3873992 | 0.75 | ADORA2A (1.00) | ADORA2AADORA1TSHRADORA3 | |
| SCHEMBL1256007 | 0.75 | ADORA2A (0.77) | ADORA2AADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090005568-A1 | Substituted 2-aminothiazoles for treating neurodegenerative diseases | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2009-01-01 | — | — | US | disclosed |
| WO-2007022415-A2 | SUBSTITUTED 2-AMINOTHIAZOLES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005568-A1 | Substituted 2-aminothiazoles for treating neurodegenerative diseases | ADORA2A, ADORA1, PARK7 | ADORA2A 1/4885ADORA1 2/4885TSHR 597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.