Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 9/20 | 0.44 |
| ▸ | AKT2 | P31751 | 9/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6862190 | 0.87 | MEN1 (0.54) | MEN1KMT2ANPC1RXFP1MAPT | |
| SCHEMBL4416906 | 0.87 | AKT1 (0.43) | AKT1AKT2MEN1KMT2ARXFP1 | |
| SCHEMBL3867128 | 0.84 | RXFP1 (0.44) | AKT1AKT2MEN1KMT2ARXFP1 | |
| SCHEMBL5659367 | 0.80 | MEN1 (0.52) | AKT1AKT2MEN1KMT2ANPC1 | |
| SCHEMBL4415141 | 0.76 | AKT1 (0.45) | AKT1AKT2PDGFRBFGFR1SRC | |
| SCHEMBL6870411 | 0.74 | MEN1 (0.58) | AKT1AKT2MEN1KMT2ANPC1 | |
| SCHEMBL12126827 | 0.73 | NPC1 (0.50) | MEN1KMT2ANPC1RXFP1MAPT | |
| SCHEMBL14607270 | 0.73 | MEN1 (0.44) | AKT1AKT2MEN1KMT2APDGFRB | |
| SCHEMBL6016381 | 0.73 | RXFP1 (0.56) | NPC1RXFP1MAPTNTRK1POLB | |
| SCHEMBL6868503 | 0.73 | KMT2A (0.64) | MEN1KMT2ANPC1RXFP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247518-A1 | 6-(2-ALKYL-PHENYL)-PYRIDO[2,3-D]PYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | HONOLD KONRAD | 2009-10-01 | — | — | US | disclosed |
| US-7550589-B2 | 6-(2-alkyl-phenyl)-pyrido[2,3-D]pyrimidines useful as protein kinase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-20070259899-A1 | 6-(2-Alkyl-Phenyl)-Pyrido[2,3-D]Pyrimidines useful as Proteine Kinase Inhibitors | HOFFMANN-LA ROCHE INC. | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247518-A1 | 6-(2-ALKYL-PHENYL)-PYRIDO[2,3-D]PYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | MAP4K2, MAP3K6, MAP3K1 | AKT1 190/4885AKT2 252/4885MEN1 3079/4885 |
| US-20070259899-A1 | 6-(2-Alkyl-Phenyl)-Pyrido[2,3-D]Pyrimidines useful as Proteine Kinase Inhibitors | MAP3K6, MAP4K2, CDK2 | AKT1 210/4885AKT2 267/4885MEN1 3074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.