Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12126619 | 0.85 | MAPT (0.54) | KMT2AMEN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6862190 | 0.84 | MEN1 (0.54) | KMT2AMEN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6870411 | 0.82 | MEN1 (0.58) | KMT2AMEN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6866229 | 0.82 | MAPT (0.58) | KMT2AMEN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6862421 | 0.82 | MEN1 (0.51) | KMT2AMEN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6866602 | 0.81 | MEN1 (0.50) | KMT2AMEN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6016328 | 0.80 | RXFP1 (0.53) | KMT2AMEN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL7703584 | 0.79 | SMN1; SMN2 (0.53) | KMT2AMEN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL1533879 | 0.79 | KMT2A (1.00) | KMT2AMEN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL29520195 | 0.79 | KMT2A (1.00) | KMT2AMEN1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187814-B1 | 5-PHENYL-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2004-08-18 | — | — | EP | disclosed |
| US-6756380-B1 | NEUROKININ 1 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE INC. | 2004-06-29 | — | — | US | disclosed |
| EP-1187814-A2 | 5-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000073278-A2 | 5-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-07 | — | — | WO | disclosed |