Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3871770 | 1.00 | EPHX1 (0.41) | EPHX1ALDH1A1TSHRHPGDMEN1 | |
| SCHEMBL187942 | 1.00 | EPHX1 (0.41) | EPHX1ALDH1A1TSHRHPGDMEN1 | |
| SCHEMBL6417917 | 0.85 | EPHX1 (0.41) | EPHX1ALDH1A1TSHRHPGDMEN1 | |
| SCHEMBL6417925 | 0.85 | EPHX1 (0.41) | EPHX1ALDH1A1TSHRHPGDMEN1 | |
| SCHEMBL6417921 | 0.85 | EPHX1 (0.41) | EPHX1ALDH1A1TSHRHPGDMEN1 | |
| SCHEMBL2152897 | 0.82 | HSD11B1 (0.46) | EPHX1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2152900 | 0.82 | HSD11B1 (0.46) | EPHX1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2153035 | 0.82 | MAPT (0.45) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2153032 | 0.82 | MAPT (0.45) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10477451 | 0.81 | EPHX1 (0.39) | EPHX1ALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247518-A1 | 6-(2-ALKYL-PHENYL)-PYRIDO[2,3-D]PYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | HONOLD KONRAD | 2009-10-01 | — | — | US | disclosed |
| US-7550589-B2 | 6-(2-alkyl-phenyl)-pyrido[2,3-D]pyrimidines useful as protein kinase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-20070259899-A1 | 6-(2-Alkyl-Phenyl)-Pyrido[2,3-D]Pyrimidines useful as Proteine Kinase Inhibitors | HOFFMANN-LA ROCHE INC. | 2007-11-08 | — | — | US | disclosed |
| EP-1794160-A1 | 6-(2-ALKYL-PHENYL) - PYRIDO[2,3-D] PYRIMIDINES USEFUL AS PROTEINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006032452-A1 | 6-(2-ALKYL-PHENYL) - PYRIDO[2,3-D] PYRIMIDINES USEFUL AS PROTEINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-30 | — | — | WO | disclosed |
| WO-2005118584-A2 | SAFRAMYCIN ANALOGS AS THERAPEUTIC AGENTS IN THE TREATMENT OF CANCER | AXYS PHARMACEUTICALS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247518-A1 | 6-(2-ALKYL-PHENYL)-PYRIDO[2,3-D]PYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | MAP4K2, MAP3K6, MAP3K1 | EPHX1 2117/4885ALDH1A1 1743/4885TSHR 4151/4885 |
| US-20070259899-A1 | 6-(2-Alkyl-Phenyl)-Pyrido[2,3-D]Pyrimidines useful as Proteine Kinase Inhibitors | MAP3K6, MAP4K2, CDK2 | EPHX1 2383/4885ALDH1A1 2387/4885TSHR 3796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.