Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1536203 | 1.00 | CASP1 (0.47) | CASP1LMNAADORA2AADORA1POLB | |
| Bromide SCHEMBL28496993 | 0.95 | CASP1 (0.44) | CASP1LMNAADORA2AADORA1POLB | |
| Bromide SCHEMBL28230753 | 0.95 | CASP1 (0.44) | CASP1LMNAADORA2AADORA1POLB | |
| SCHEMBL29876207 | 0.94 | — | — | |
| SCHEMBL8465809 | 0.94 | CASP1 (0.50) | CASP1LMNAADORA2AADORA1POLB | |
| SCHEMBL29485005 | 0.94 | — | — | |
| SCHEMBL25853 | 0.94 | — | — | |
| SCHEMBL9579151 | 0.94 | CASP1 (0.50) | CASP1LMNAADORA2AADORA1POLB | |
| SCHEMBL175612 | 0.94 | CASP1 (0.50) | CASP1LMNAADORA2AADORA1POLB | |
| SCHEMBL9583239 | 0.94 | CASP1 (0.50) | CASP1LMNAADORA2AADORA1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109776951-B | Temperature-resistant flame retardant composition for enabling polypropylene to reach V2 flame retardant grade, and preparation method and application thereof | 清远市普塞呋磷化学有限公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-109734959-B | Temperature-resistant free radical initiator and preparation method and application thereof | 清远市普塞呋磷化学有限公司 | 2021-03-23 | — | — | CN | disclosed |
| US-7517926-B2 | Flame-retardant polymeric composition with low halogen content, a concentrate of said composition, and a method for preparing said composition | DIAP S.R.L. (IT) | 2009-04-14 | — | — | US | disclosed |
| US-20070004831-A1 | Flame-retardant polymeric composition with low halogen content, a concentrate of said composition, and a method for preparing said composition | DIAP S.R.L. (IT) | 2007-01-04 | — | — | US | disclosed |
| EP-1660576-A2 | A FLAME-RETARDANT POLYMERIC COMPOSITION WITH LOW HALOGEN CONTENT, A CONCENTRATE OF SAID COMPOSITION, AND A METHOD FOR PREPARING SAID COMPOSITION | Diap S.r.l. (IT) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019330-A2 | A FLAME-RETARDANT POLYMERIC COMPOSITION WITH LOW HALOGEN CONTENT, A CONCENTRATE OF SAID COMPOSITION, AND A METHOD FOR PREPARING SAID COMPOSITION | DIAP S.R.L. (IT) | 2005-03-03 | — | — | WO | disclosed |
| EP-0200217-B1 | POLYMERIC COMPOSITIONS ENDOWED WITH IMPROVED FLAME-RESISTANCE PROPERTIES | Himont Incorporated (US) | 1993-03-03 | — | — | EP | disclosed |
| US-4028333-A | POLYOLEFINS | VELSICOL CHEMICAL CORPORATION (US) | 1977-06-07 | — | — | US | disclosed |