Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407499 | 0.87 | AGTR1 (0.61) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL3872809 | 0.86 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL12730813 | 0.84 | AGTR1 (0.57) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL3873970 | 0.82 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL14169520 | 0.82 | AGTR1 (0.53) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL5773556 | 0.82 | AGTR1 (0.55) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL5360591 | 0.81 | AGTR1 (0.52) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL4960875 | 0.81 | AGTR1 (0.55) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL6755888 | 0.81 | AGTR1 (0.59) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL5360583 | 0.80 | AGTR1 (0.51) | AGTR1AGTR2ABCC4ABCB11PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899328-B1 | A PROCESS FOR THE PREPARATION OF LOSARTAN DERIVATIVES BY CHLORINATION AND REDUCTION OF THE RESPECTIVE 1H-IMIDAZOLE-5-CARBALDEHYDES | KRKA D D NOVO MESTO (SI) | 2009-03-04 | — | — | EP | disclosed |
| EP-1741711-A1 | A process for the preparation of losartan derivatives by chlorination and reduction of the respective 1H-imidazole-5-carbaldehydes | KRKA, D.D., Novo Mesto (SI) | 2007-01-10 | — | — | EP | disclosed |