Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.56 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.55 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.52 |
| ▸ | TNF | P01375 | 3/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | MUSK | O15146 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3874709 | 0.90 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3887717 | 0.90 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3874639 | 0.90 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3877347 | 0.89 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3883701 | 0.88 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3879428 | 0.88 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3879350 | 0.87 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3874230 | 0.87 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3876443 | 0.87 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3884806 | 0.87 | PTK2B (0.55) | MAPK14MAPK13MAPK12MAPK11DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541368-B2 | 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{3-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-ylmethyl]-phenyl}-urea; use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and tumor necrosis factor (TNF) | AVENTIS PHARMACEUTICALS INC. (US) | 2009-06-02 | — | — | US | disclosed |
| EP-1622610-B1 | 1-(2H-PYRAZOL-3-YL)-3-{4-[1-(BENZOYL)-PIPERIDIN-4-YLMETHYL]-PHENYL}-UREA DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF P38 KINASE AND/OR TNF INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AVENTIS PHARMA INC (US) | 2006-12-20 | — | — | EP | disclosed |