Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 3/20 | 0.38 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.38 |
| ▸ | GABRE | P78334 | 2/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7578630 | 1.00 | GABRR1 (0.38) | GABRR1GABRPGABRDGABRA1GABRB1 | |
| Acetic Acid SCHEMBL10585177 | 0.98 | GABRR1 (0.39) | GABRR1GABRPGABRDGABRA1GABRB1 | |
| Acetic Acid SCHEMBL20387 | 0.98 | GABRR1 (0.39) | GABRR1GABRPGABRDGABRA1GABRB1 | |
| Acetic Acid SCHEMBL2167990 | 0.98 | GABRR1 (0.39) | GABRR1GABRPGABRDGABRA1GABRB1 | |
| Acetic Acid SCHEMBL10888533 | 0.93 | GABRP (0.37) | GABRR1GABRPGABRDGABRA1GABRB1 | |
| Acetic Acid SCHEMBL10889391 | 0.93 | GABRP (0.37) | GABRR1GABRPGABRDGABRA1GABRB1 | |
| Acetic Acid SCHEMBL10888521 | 0.93 | GABRP (0.37) | GABRR1GABRPGABRDGABRA1GABRB1 | |
| Bicarbonate SCHEMBL7190421 | 0.88 | GABRR1 (0.37) | GABRR1GABRPGABRDGABRA1GABRB1 | |
| Acetic Acid SCHEMBL17201408 | 0.86 | GABRR1 (0.46) | GABRR1GABRPGABRDGABRA1GABRB1 | |
| Acetic Acid SCHEMBL40807 | 0.84 | CA1 (0.39) | GABRR1GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4284435-A | Method for spray cleaning painted surfaces | S. C. JOHNSON & SON, INC. (US) | 1981-08-18 | — | — | US | claimed |
| US-8905088-B2 | Mixing apparatus and methods of using the same | R. LEWIS TECHNOLOGIES, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20120236681-A1 | MIXING APPARATUS AND METHODS OF USING THE SAME | R. LEWIS TECHNOLOGIES, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| US-7530373-B2 | Mixing apparatus and methods using the same | R. LEWIS TECHNOLOGIES, INC. (US) | 2009-05-12 | — | — | US | disclosed |
| US-7140405-B2 | Mixing apparatus | RELEVANT ENGINEERING DEVELOPMENT (US) | 2006-11-28 | — | — | US | disclosed |
| US-20040264295-A1 | Mixing apparatus | R. LEWIS TECHNOLOGIES, INC. | 2004-12-30 | — | — | US | disclosed |
| US-20040261887-A1 | Mixing apparatus and methods using the same | R. LEWIS TECHNOLOGIES, INC. | 2004-12-30 | — | — | US | disclosed |
| US-20040266658-A1 | Cleaning formulations and methods for manufacturing the same | R. LEWIS TECHNOLOGIES, INC. | 2004-12-30 | — | — | US | disclosed |
| US-5424010-A | Light duty liquid detergent composition containing 3-methyl-3-methoxy-butanol | DULIBA EDWARD P (US) | 1995-06-13 | — | — | US | disclosed |
| US-4284435-A | Method for spray cleaning painted surfaces | S. C. JOHNSON & SON, INC. (US) | 1981-08-18 | — | — | US | disclosed |