Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | CLPP | Q16740 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680045 | 1.00 | GRM5 (0.46) | GRM5CLPPDYRK1ADRD2DRD4 | |
| SCHEMBL3887570 | 0.90 | GRM5 (0.54) | GRM5CLPPDYRK1ANPC1RAB9A | |
| SCHEMBL408938 | 0.90 | GRM5 (0.54) | GRM5CLPPDYRK1ANPC1RAB9A | |
| SCHEMBL3887575 | 0.89 | NPC1 (0.42) | GRM5CLPPDRD2DRD4NPC1 | |
| SCHEMBL412447 | 0.83 | NPC1 (0.62) | GRM5CLPPDRD2DRD4NPC1 | |
| SCHEMBL28761878 | 0.81 | BTK (0.44) | GRM5CLPPDYRK1ANPC1RAB9A | |
| SCHEMBL414961 | 0.78 | HSD11B1 (0.46) | GRM5CLPPKMT2APOLBMEN1 | |
| SCHEMBL10211651 | 0.72 | HDAC4 (0.62) | DRD2DRD4NPC1RAB9AKMT2A | |
| SCHEMBL409828 | 0.72 | NPC1 (0.56) | GRM5NPC1RAB9AKDM5AKMT2A | |
| SCHEMBL3320973 | 0.72 | GLA (0.60) | GRM5DRD2DRD4RAB9AKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2030970-A1 | Allosteric modulators of metabotropic glutamate receptors | ADDEX Pharma S.A. (CH) | 2009-03-04 | — | — | EP | disclosed |
| EP-1685105-B1 | ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2008-10-15 | — | — | EP | disclosed |