Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 14/20 | 0.59 |
| ▸ | CTSD | P07339 | 10/20 | 0.59 |
| ▸ | BCHE | P06276 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3876042 | 1.00 | BACE1 (0.59) | BACE1CTSDBCHE | |
| SCHEMBL10570700 | 0.89 | CTSK (0.54) | — | |
| SCHEMBL6697232 | 0.88 | BACE1 (0.73) | BACE1CTSDBCHE | |
| Hydrochloric Acid SCHEMBL3352330 | 0.87 | BACE1 (0.72) | BACE1CTSDBCHE | |
| SCHEMBL6110948 | 0.84 | BCHE (0.68) | BACE1CTSDBCHE | |
| SCHEMBL3029758 | 0.83 | CTSK (0.55) | — | |
| SCHEMBL3348911 | 0.82 | BCHE (0.65) | BACE1CTSDBCHE | |
| SCHEMBL3348906 | 0.82 | BCHE (0.65) | BACE1CTSDBCHE | |
| SCHEMBL6703596 | 0.81 | BACE1 (0.74) | BACE1CTSDBCHE | |
| SCHEMBL3351034 | 0.80 | BCHE (0.68) | BACE1CTSDBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557137-B2 | Gamma-lactams as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-07-07 | — | — | US | disclosed |
| US-20070265331-A1 | Novel gamma-lactams as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265331-A1 | Novel gamma-lactams as beta-secretase inhibitors | BACE1, APP, BACE2 | BACE1 1/4885CTSD 251/4885BCHE 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.