Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28701694 | 0.82 | KMT2A (0.44) | KMT2ASMN1; SMN2CYP2C19MEN1CYP3A4 | |
| SCHEMBL3380721 | 0.80 | KMT2A (0.43) | KMT2ASMN1; SMN2CYP2C19MEN1CYP3A4 | |
| SCHEMBL27276534 | 0.77 | KMT2A (0.41) | KMT2ASMN1; SMN2CYP2C19MEN1CYP3A4 | |
| SCHEMBL7584563 | 0.76 | CYP1A2 (0.42) | KMT2ASMN1; SMN2CYP2C19MEN1CYP3A4 | |
| SCHEMBL3176699 | 0.74 | CYP1A2 (0.50) | KMT2ASMN1; SMN2CYP2C19MEN1CYP3A4 | |
| SCHEMBL3103814 | 0.73 | KMT2A (0.38) | KMT2ASMN1; SMN2CYP2C19MEN1CYP3A4 | |
| SCHEMBL16798748 | 0.73 | POLB (0.45) | KMT2ASMN1; SMN2CYP2C19MEN1CYP3A4 | |
| SCHEMBL28877762 | 0.73 | ALDH1A1 (0.41) | KMT2ASMN1; SMN2CYP2C19MEN1CYP3A4 | |
| SCHEMBL6933247 | 0.72 | KMT2A (0.47) | KMT2ASMN1; SMN2CYP2C19MEN1CYP3A4 | |
| SCHEMBL5712822 | 0.69 | KMT2A (0.44) | KMT2ASMN1; SMN2CYP2C19MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120555-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | Heller, Adam (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008094664-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | HELLER ADAM (US) | 2008-08-07 | — | — | WO | disclosed |