Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3875114 | 0.90 | MAP2K1 (0.38) | MEN1KMT2AALDH1A1MAP2K1MAPT | |
| SCHEMBL3880754 | 0.86 | IDO1 (0.56) | MEN1KMT2AIDO1MAP2K1MAP2K2 | |
| SCHEMBL3887781 | 0.79 | MAP2K1 (0.43) | MAP2K1MAP2K2 | |
| SCHEMBL3887785 | 0.79 | MAP2K1 (0.43) | MAP2K1MAP2K2 | |
| SCHEMBL5177890 | 0.76 | MAP2K1 (0.60) | MEN1KMT2AALDH1A1MAP2K1METAP2 | |
| SCHEMBL3873028 | 0.73 | MAP2K1 (0.52) | MEN1KMT2AIDO1ALDH1A1MAP2K1 | |
| SCHEMBL3975034 | 0.71 | MAP2K1 (0.41) | MEN1KMT2AALDH1A1AKR1C3AKR1C2 | |
| SCHEMBL6035661 | 0.71 | CLCN2 (0.54) | MEN1KMT2AIDO1ALDH1A1AKR1C3 | |
| SCHEMBL22852818 | 0.71 | TAS2R14 (0.60) | ALDH1A1AKR1C3AKR1C2MPOKDM4E | |
| SCHEMBL29382916 | 0.71 | TAS2R14 (0.60) | ALDH1A1AKR1C3AKR1C2MPOKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828184-B1 | [1,2,4]TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | MERCK SERONO SA (CH) | 2009-09-16 | — | — | EP | disclosed |
| EP-1828184-B1 | [1,2,4]TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | MERCK SERONO SA (CH) | 2009-09-16 | — | — | EP | disclosed |
| US-20070299103-A1 | [1,2,4]Triazolo[4,3-A]Pyridine Derivatives for the Treatment of Hyperproliferative Diseases | MERCK SERONO SA (CH) | 2007-12-27 | — | — | US | disclosed |
| US-20070299103-A1 | [1,2,4]Triazolo[4,3-A]Pyridine Derivatives for the Treatment of Hyperproliferative Diseases | MERCK SERONO SA (CH) | 2007-12-27 | — | — | US | disclosed |
| US-20070299103-A1 | [1,2,4]Triazolo[4,3-A]Pyridine Derivatives for the Treatment of Hyperproliferative Diseases | MERCK SERONO SA (CH) | 2007-12-27 | — | — | US | disclosed |
| EP-1828184-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | LABORATOIRES SERONO S.A. (CH) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006058752-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | LABORATOIRES SERONO S.A. (CH) | 2006-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299103-A1 | [1,2,4]Triazolo[4,3-A]Pyridine Derivatives for the Treatment of Hyperproliferative Diseases | CDK4, CDK3, BRAF | MEN1 1626/4885KMT2A 2072/4885IDO1 1077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.